Initial study on TMPRSS2 p.Val160Met genetic variant in COVID-19 patients

Authors: Laksmi WulandariBerliana HamidahCennikon PakpahanNevy Shinta DamayantiNeneng Dewi KurniatiChristophorus Oetama AdiatmajaMonica Rizky WigianitaSoedarsonoDominicus HusadaDamayanti TinduhCita Rosita Sigit PrakoeswaAnang EndaryantoNi Nyoman Tri PuspaningsihYasuko MoriMaria Inge LusidaKazufumi Shimizu & Delvac Oceandy 

Coronavirus disease 2019 (COVID-19) is a global health problem that causes millions of deaths worldwide. The clinical manifestation of COVID-19 widely varies from asymptomatic infection to severe pneumonia and systemic inflammatory disease. It is thought that host genetic variability may affect the host’s response to the virus infection and thus cause severity of the disease. The SARS-CoV-2 virus requires interaction with its receptor complex in the host cells before infection. The transmembrane protease serine 2 (TMPRSS2) has been identified as one of the key molecules involved in SARS-CoV-2 virus receptor binding and cell invasion. Therefore, in this study, we investigated the correlation between a genetic variant within the human TMPRSS2 gene and COVID-19 severity and viral load.

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