Category: Antibody

Adverse effects of COVID-19 vaccines and measures to prevent them

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Authors: Kenji Yamamoto Virol J. 2022; 19: 100. Published online 2022 Jun 5. doi: 10.1186/s12985-022-01831-0 PMCID: PMC9167431PMID: 35659687 Abstract Recently, The Lancet published a study on the effectiveness of COVID-19 vaccines and the waning of immunity with time. The study showed that immune function among vaccinated individuals 8 months after the administration of two doses of COVID-19 vaccine was lower than that among the […]

Consequences of COVID-19 for the Pancreas

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Authors: Urszula Abramczyk,1,*Maciej Nowaczyński,2Adam Słomczyński,2Piotr Wojnicz,2Piotr Zatyka,2 and Aleksandra Kuzan1 Int J Mol Sci. 2022 Jan; 23(2): 864.Published online 2022 Jan 13. doi: 10.3390/ijms23020864 Abstract Although coronavirus disease 2019 (COVID-19)-related major health consequences involve the lungs, a growing body of evidence indicates that COVID-19 is not inert to the pancreas either. This review presents a summary of the molecular mechanisms […]

Link between fever, diarrhea, severe COVID-19, and persistent anti-SARS-CoV-2 antibodies

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Authors: By Dr. Liji Thomas, MD Jan 7 2021 Ever since the coronavirus disease 2019 (COVID-19) pandemic began, there have been many attempts to understand the nature and duration of immunity against the causative agent, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A new preprint research paper appearing on the medRxiv* server describes a link between the […]

Coronavirus (Covid-19)

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A collection of articles and other resources on the Coronavirus (Covid-19) outbreak, including clinical reports, management guidelines, and commentary. CORONAVIRUS (COVID-19)     VACCINE RESOURCES     VACCINE FAQ https://www.nejm.org/coronavirus All Journal content related to the Covid-19 pandemic is freely available. ORIGINAL ARTICLEConvalescent Plasma for High-Risk Covid-19F.K. Korley and OthersPatients who were seen in emergency departments within 7 days after the onset of Covid-19 symptoms […]

Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19

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Authors: MartinDugasa1TanjaGrote-Westrickb1UtaMerledMichaelaFontenaylmAndreas E.KremerhFrankHansesijRichardVollenbergcEvaLorentzenbShilpaTiwari-BecklerdJérômeDucheminlSyrineEllouzelMarcelVetterhJuliaFürsthPhilippSchusterkTobiasBrixaClaudia M.DenkingerfgCarstenMüller-TidoweHartmutSchmidtc…JoachimKühnb1 Highlights Does prior infection with seasonal human coronavirus OC43 protect against critical COVID-19?• Findings: In an international multi-center study inpatients without anti-HCoV OC43 NP antibodies had an increased risk of critical disease.• Meaning: Prior infections with seasonal HCoV OC43 have a protective effect against critical COVID-19. Abstract Background The vast majority of COVID-19 patients experience […]

Lack of antibodies against seasonal coronavirus OC43 nucleocapsid protein identifies patients at risk of critical COVID-19

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Authors: Martin Dugas 1, Tanja Grote-Westrick 2, Uta Merle 3, Michaela Fontenay 4, Andreas E Kremer 5, Frank Hanses 6, Richard Vollenberg 7, Eva Lorentzen 8, Shilpa Tiwari-Heckler 9, Jérôme Duchemin 10, Syrine Ellouze 11, Marcel Vetter 12, Julia Fürst 13, Philipp Schuster 14, Tobias Brix 15, Claudia M Denkinger 16, Carsten Müller-Tidow 17, Hartmut Schmidt 18, Phil-Robin Tepasse 19, Joachim Kühn 20 Abstract Background: The vast majority of COVID-19 patients experience a mild disease. However, a minority suffers from critical disease with substantial morbidity and mortality. Objectives: To identify individuals at risk of critical COVID-19, […]

Trained Innate Immunity, Epigenetics, and Covid-19

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Authors: Alberto Mantovani, M.D., and Mihai G. Netea, M.D. Innate immunity is mediated by different cell types and cell-associated or fluid-phase pattern-recognition molecules and plays a key role in tissue repair and resistance against pathogens.1 Exposure to selected vaccines, such as bacille Calmette–Guérin (BCG) or microbial components, can increase the baseline tone of innate immunity and trigger […]

Multi-layered transcriptomic analyses reveal an immunological overlap between COVID-19 and hemophagocytic lymphohistiocytosis associated with disease severity

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Authors: Lena F. Schimkea,5, Alexandre H.C. Marquesa, Gabriela Crispim Baiocchia, Caroline Aliane de Souza Pradob Dennyson Leandro M. Fonsecab , Paula Paccielli Freirea , Desirée Rodrigues Plaçab , Igor Salerno Filgueirasa ,Ranieri Coelho Salgadoa, Gabriel Jansen-Marquesc, Antonio Edson Rocha liveirab, Jean PierreSchatzmann Perona, José Alexandre Marzagão Barbutoa,d, Niels Olsen Saraiva Camaraa, Vera Lúcia Garcia Calicha […]

Good news: Mild COVID-19 induces lasting antibody protection

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People who have had mild illness develop antibody–producing cells that can last lifetime Authors: by Tamara Bhandari•May 24, 2021 Months after recovering from mild cases of COVID-19, people still have immune cells in their body pumping out antibodies against the virus that causes COVID-19, according to a study from researchers at Washington University School of Medicine […]

COVID-19 Science Update released: June 4, 2021 Edition 92

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Authors: From the Office of the Chief Medical Officer, CDC COVID-19 Response, and the CDC Library, Atlanta GA. Intended for use by public health professionals responding to the COVID-19 pandemic. PEER-REVIEWED Safety, immunogenicity, and efficacy of the BNT162b2 COVID-19 vaccine in adolescents.external icon Frenck et al. NEJM (May 27, 2021). Key findings: Vaccine efficacy was 100% (95% CI 75.3%-100%) […]